Benign liver lesion associated with a long history of oral contraceptives and glycogen storage disease type I is known as what?

Benign liver lesion associated with a long history of oral contraceptives and glycogen storage disease type I is known as what?

• A. Hepatic Adenoma
• B. Focal Nodular Hyperplasia
• C. Hemangioma
• D. Hepatocellular Carcinoma

Answer: (A)

Hepatic adenoma is the benign liver lesion most classically linked to estrogen exposure from oral contraceptives and to glycogen storage disease type I. Estrogen-containing OCPs stimulate hepatocyte growth, increasing the risk of adenoma formation, and glycogen storage disease I (von Gierke disease) carries a known association with hepatic adenomas due to chronic metabolic changes in the liver. This combination makes hepatic adenoma the best match for a lesion in a patient with long-term OCP use and GSD I. Hemangioma and focal nodular hyperplasia have different typical associations and imaging features, and hepatocellular carcinoma is malignant, not the lesion described here.

Hepatic adenoma is the benign liver lesion most classically linked to estrogen exposure from oral contraceptives and to glycogen storage disease type I. Estrogen-containing OCPs stimulate hepatocyte growth, increasing the risk of adenoma formation, and glycogen storage disease I (von Gierke disease) carries a known association with hepatic adenomas due to chronic metabolic changes in the liver. This combination makes hepatic adenoma the best match for a lesion in a patient with long-term OCP use and GSD I. Hemangioma and focal nodular hyperplasia have different typical associations and imaging features, and hepatocellular carcinoma is malignant, not the lesion described here.